Frontiers in Human Neuroscience

| 2020

A Single Session of Anodal Cerebellar Transcranial Direct Current Stimulation Does Not Induce Facilitation of Locomotor Consolidation in Patients With Multiple Sclerosis

Background

Multiple sclerosis (MS) may cause variable functional impairment. The discrepancy between functional impairment and brain imaging findings in patients with MS (PwMS) might be attributed to differential adaptive and consolidation capacities. Modulating those abilities could contribute to a favorable clinical course of the disease.

Objectives

We examined the effect of cerebellar transcranial direct current stimulation (c-tDCS) on locomotor adaptation and consolidation in PwMS using a split-belt treadmill (SBT) paradigm.

Methods

40 PwMS and 30 matched healthy controls performed a locomotor adaptation task on a SBT. First, we assessed locomotor adaptation in PwMS. In a second investigation, this training was followed by cerebellar anodal tDCS applied immediately after the task ipsilateral to the fast leg (T0). The SBT paradigm was repeated 24 h (T1) and 78 h (T2) post-stimulation to evaluate consolidation.

Results

The gait dynamics and adaptation on the SBT were comparable between PwMS and controls. We found no effects of offline cerebellar anodal tDCS on locomotor adaptation and consolidation. Participants who received the active stimulation showed the same retention index than sham-stimulated subjects at T1 (p = 0.33) and T2 (p = 0.46).

Conclusion

Locomotor adaptation is preserved in people with mild-to-moderate MS. However, cerebellar anodal tDCS applied immediately post-training does not further enhance this ability. Future studies should define the neurobiological substrates of maintained plasticity in PwMS and how these substrates can be manipulated to improve compensation. Systematic assessments of methodological variables for cerebellar tDCS are urgently needed to increase the consistency and replicability of the results across
experiments in various settings.

Keywords

multiple sclerosis, cerebellar tDCS, split-belt treadmill, locomotor adaptation, consolidation

Author/s

Carine Nguemeni, György A. Homola, Luis Nakchbandi, Mirko Pham, Jens Volkmann, Daniel Zeller

Institution / Department

Department of Neurology, University Hospital of Würzburg

Upcoming Events
Need help?
Want a live demo?
Interested in prices?
Want to say hello?
Always just a call away
+49 89 2000 301 60

Wireless Data Transmission


The wireless data transmission from OpenGo Sensor Insoles to the mobile device uses intelligent handshake technology to avoid the loss of data packages, even when the connection quality is below 100 %.

Typical wireless range of the Bluetooth Low Energy connection in indoor settings is ≥ 10 m, in in-field settings up to 20 m.

Get support

Check our FAQ database for answers to frequently asked questions!


Describe your issue in as much detail as possible. Include screenshots or files if applicable.


Have a general inquiry?

Write us a message for general questions about products and solutions or if you’d like to discuss other topics.


Select your desired system

moticon-rego-logo

The cutting edge test based outcome assessment system for health professionals and trainers

opengo-logo-orange

The most versatile toolkit for free data acquisition and comprehensive analytics in research

Select your desired system

moticon-rego-logo

The cutting edge test based outcome assessment system for health professionals and trainers

opengo-logo-orange

The most versatile toolkit for free data acquisition and comprehensive analytics in research

The form was sent successfully.

You will be contacted shortly.

Get an individual quote

Please provide the quantity of sensor insoles, software licenses or other items for your individual quote. Sensor insole sizes can be chosen upon final order (not relevant for your quote).

A problem was detected in the following Form. Submitting it could result in errors. Please contact the site administrator.

Article/s

Amount

ReGo App

More details >

Free of charge

ReGo Sensor Insoles

1 pair - all sizes same price

More details >

ReGo Accessories

More details >

Product Bag

For 6 pairs of sensor insoles

Get an individual quote

Please provide the quantity of sensor insoles, software licenses or other items for your individual quote. Sensor insole sizes can be chosen upon final order (not relevant for your quote).

A problem was detected in the following Form. Submitting it could result in errors. Please contact the site administrator.

Article/s

Amount

OpenGo App

More details >

Free of charge

OpenGo Sensor Insoles

1 pair - all sizes same price

More details >

OpenGo Software

More details >

BASIC Module

ANALYZE Module

VIDEO Module

GAIT Module

BALANCE Module

JUMP Module

OpenGo Accessories

More details >

Coin Cell Batteries

1 pair for 1 pair of sensor insoles

Coin Cell Charger

Battery Lid

For sensor insole

Product Bag

For 6 pairs of sensor insoles

Coin Cell Bag

For 20 pairs of coin cells

Sensor Insoles Sack

For 1 pair of sensor insoles